Protective effect of ethanolic leaf extract of myrianthus arboreus on indomethacin induced gastric ulcer in adult male wistar rats

Gastric ulcers are a common gastrointestinal disease with complex etiology. It manifests various signs and symptoms, which, in severe cases, could be life-threatening, especially developing countries. Medicinal plants have been known to exhibit therapeutic potential minimal adverse effects thus employed treating diseases. This study evaluated the effect of ethanolic Myrianthus arboreus leaf extract on indomethacin-induced gastric adult male Wistar rats. Twenty-five rats were divided into five groups each: group A received distilled water; B water for 14 days, 30 mg/kg body weight indomethacin after 24 hours fasting. Group C 20 omeprazole days Groups D E 50 100 M. arboreus, respectively, each The ulcer index, antioxidant parameters, pH, histopathology stomach laboratory experiment. results showed significant increase index malondialdehyde caused by indomethacin, while there was reduction glutathione, superoxide dismutase, hydrogen ion concentration (pH), as well extensive damage mucosa. In contrast, both significantly improved these damages. revealed that has gastro-protective comparable ulcer.